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@growing_daniel yeah homeless tier

the infrastructural benefit of colonialism is easy to identify and the destruction of local state capacity is much harder

@blamelessjay @Rationalbot 😭he is calling me a wordcel

@wdiamond_econ True

@foursteez Fuck the British raj. May the crown shatter and burn

@keshavadhyay It’s a mistake to think that internal conflicts lowers gdp in equilibrium; it ended up being a net boon to Europe

@Arty_Lee12 Lolol

@Arty_Lee12 Link your project

@growing_daniel Had to unlike

@MegaBasedChad @keshavadhyay point still stands competition is good

@mikedemarais vidya obviously

@keshavadhyay @MegaBasedChad no way to tell what might have happened were Maratha empire to evolve into a stable state

@cauchyfriend goddamn it u r correct sry

ok get in here to join https://discord.gg/mkpvqnzA

@Mimi_Rose_01 @growing_daniel the homeless all know each other. those guys are saving each other from heroin overdoses on the reg. no closer bond than that

@ProofOfRatio lmfao

@ollyrobot definitely chinese

>tfw i missed the golden age of silicon valley its over

@Pavel_Asparagus Physical place

@ghosttyped yeah that’s like any one of Rome’s far less impressive successor states

@nachkari Minus the hot people

@andrejwagmi Lol

@andrei_kuznetsv Facts

@andrejwagmi So true

@deathracefora even recognizing this is alpha

@ollyrobot it’s being fought rn

@ConejoCapital delet

@tarunchitra RoonDAO vs TarunDAO is how ww3 will start

the damage done by the American regulatory state doesn’t end at our borders. the entire world is in the de facto american regulatory regime due to path dependence of technology

we need a multipolar world to avoid a global dark age

@J_K_Chesterton Yes

@MegaBasedChad all the really important regulation happens at the federal level california is just somewhat more strict on environment and privacy stuff

@sheslostheplot exactly, all regulation should have an end of life clause

@abettertake @sheslostheplot Yeah I’m aware, federal regulation that comes from the executive branch bureaucracy especially should have sunset clause on every last thing

when will we see our first fertility fascists

@MegaBasedChad This why the government must ban opendoor before they all revolt

@PrinceVogel @balajis rip

@idanthyrsus Too broad a generalization

@minordissent @youngprotean @the_lonelocust go forth and be fruitful child

i get this 3 times a day now. it’s over

there’s a type of guy who is: - a staunch atheist - only buys index funds - highly logical, doesn’t make broad claims - didn’t get laid in college i love them. they’re the footsoldiers of science and engineering

@wdiamond_econ Lmao

@0x8008135 Except it’s not really a compliment

note I said footsoldiers. science and engineering would not progress without visionary creative schizos as leaders

@bryancsk they love the pain I inflict

@AnnaKooner Lmao

@dystopiabreaker One day

@Hellachans At this point I don’t know how to turn it off

@Mike_Hinton I was +, it’s fine now

@halvorz Bardeen and Shockley; the prototypical autist and schizo pairing. They make for very good lab partners

@Mimi_Rose_01 @Edgar_DOP well mimi, lucky for you i'm a schizo

@girlbossintech both the left and right guys can be wordcels

@cateliseh lol save you a footsoldier or a leader?

@nachkari exactly

this is just called indian standard time https://x.com/WholeMarsBlog/status/1483298784083800068

@RichDecibels @andrei_kuznetsv i didn't invent it; merely popularized

@RichDecibels @andrei_kuznetsv the visuospatial vs verbal components of iq are well known

@RichDecibels @andrei_kuznetsv true

@PatrickFIanagan @krrishd nice i'm down

@nickcammarata citys done for

@growing_daniel @nickcammarata u telling me all cities are done for

@metakuna 100%

@eigenrobot i'm crashing this vibe, with no survivors

@natalya_sukmeov @eigenrobot it would be extremely cringe ... for you

this is my legacy. i'll never accomplish anything else on this earth

@0xadepti @0xfbifemboy Idk I didn’t enter this

the greatest failure of technological society is def the birth rate thing

@default_dad Facts

@BenCS13 Lol no

@BenCS13 Have you seen Japan

@Noahpinion hmm true

@Noahpinion hopefully we gets periods of decay and explosion but I don’t want to live through a decay time

@conorduffy_7 based?!!

@ollyrobot wait @eigenrobot are you going

@deepfates it’s one of the prereqs but not all of them imo

@deepfates lots of people slaving away in the poasting mines for years never reaching product market fit

@deepfates survivor bias

@lalaAlicelala @unknownxruiz So true

@bungoman @deepfates Based bungoman proving me correct

@BasQuetzal god was weak as hell if we managed to kill him already

@andrejwagmi He sucked so bad lmao

@andrejwagmi He has two modes I’ve noticed 1) curt, businesslike, usually reserved for executives, but very human 2) addressing the masses (verbose, grandiose, appears like a lizard)

@andrejwagmi (2) it was basically just a rally the troops event

@quantumVerd @nickcammarata So true

@Mimi_Rose_01 @quantumVerd @nickcammarata I’m in

@Mimi_Rose_01 @quantumVerd @nickcammarata Have you ever seen a CIA blacksite?

@eigenrobot @ollyrobot Ok that adds up

keep in mind the first type of guy is just as often a lawyer or an accountant wordcel v rotator is a separate axis

@Mimi_Rose_01 Yes

@abettertake @ollyrobot @eigenrobot as of now no but I might buy a day pass

@abettertake @ollyrobot @eigenrobot when you’re a niche internet microceleb they just let you do things

@Rididelduol @ollyrobot @abettertake @eigenrobot none of these words are in the Bible

@MegaBasedChad memorization is the first step to generalization

@hoffsbeefs Yep I bet

ok let’s talk about this. there’s nothing in biology that requires unknown physics to figure out. its all information processing and molecular mechanics. so we can assume that given a long enough timeframe eventually synthetic wombs will be possible

so they’ll use it in hospitals to save extremely premature babies and unwanted embryos and such. from there it cascades: infertile women demand womb tank tech rather than making a surrogate in India do it instead (which is quite a bit more disturbing for most)

they’ll then immediately become commercially inevitable due to potential use by the meat industry to print livestock at scale. then, people will notice that we’re not using this miracle technology to save premie babies and abortions, and what kind of monster lets babies die.

finally most taboo around synthetic wombs is done for and the rest of Pandora’s box will be unleashed. much of it will seem disturbing to today’s humans and uninteresting to future contemporaries, and the cycle repeats

@Willyintheworld Btw I’m being simplistic about biology bc it’s funny

@Willyintheworld Lol true

despite these capabilities I don’t think it’ll result in mass produced baby dystopia. why? because the value of human life is increasing over time and shows no signs of abating — tolerable deaths are trending to zero in drug testing or nuclear plants or anything else

“human rights” have been inflating for past 100s of years i don’t see why it would stop now

@realtimeai Nah

@DantzlerLowe Not about economics but rather morals

@El_Fusilad0 To indicate that it’s nebulous and expansive not to deride the concept

@alt1na1 Ur right but there’s nothing more disgusting than humanity dying out

@alt1na1 Between negative pop growth and womb tanks I’ll always choose the tanks

@alt1na1 lol if you have to keep Africa as a baby farm by refusing to modernize it that’s not a solution

@alt1na1 I want them to have kids but also I don’t want the current kids to die of malaria

@alt1na1 Ya isn’t that what bill gates is doing I don’t get ur point

@alt1na1 When you make societies richer and healthier they start wanting birth control nothing u can do about it

@alt1na1 what is the outconversion rate of LDS tho

@Noahpinion @minney_cat We’ve never met! Let’s do it

@alt1na1 Ok but u get my point - lotta people leave LDS and go back to normal birth rates

@aquariusacquah lmfao

@TheCaptain_Nemo im pretty goofy

@HoChiScreamin its just the previous thing i tweeted

@Noahpinion pure wordcel hours rn

statistical mechanics is so cool i wish gamma function was real

@alt1na1 @normonics Lol I’m mostly trolling

@J_K_Chesterton @Noahpinion Nope

@AvidHalaby @alt1na1 Blackpill

@jeff82874662 @alt1na1 don’t check the QTs to this …

were going to have to get used to the fact that grimes is ingroup now

@ollyrobot so she’ll be right at home in ingroup 🤣

@andrejwagmi So true

“Ingroup” is not an ironic overture to the SSC post. Ingroup is a social technology invented by big accounts to create a nebulous feeling of togetherness and you’re playing right into it

@dystopiabreaker Isn’t everything by default surveiled on blockchain

@andrejwagmi Literally me

@typecfemale Time to log off

@andrejwagmi Rahul would never text me something like this. He would FaceTime me and say it to my face

@MegaBasedChad the real transition from lower to middle class that he’s referencing is the Hopium of career. the lower class already gave up and tried to start families

i love how there are like 10 million IVF kids alive today, you probably run into a few, and nobody really cares despite moral panic like 2 culture war cycles ago

also i suggest people take that into consideration when predicting future culturak responses to new genomic or reproductive techs, for better or worse

@ja3k_ Confounded by a million things

@ja3k_ Latter

@halvorz there’s like 5 of them and they’re all on twitter

@nickcammarata @himbodhisattva ingroup bene gesserit

@turrible_tao If it were true the price would be paid by the local company that’s headhunting foreign talent so it’s a bit murky

@turrible_tao You’re correct that there’s some sort of immigration sink capacity we’re auctioning off but it’s more like rent seeking

@Mimi_Rose_01 True

@averyfjames Where did I say it’s unethical?

@CaesarSalad99 It’s a good argument but all this infrastructure was built by people who are long dead

@ellegist @mechanical_monk and that’s why it has to be done

@tolstoybb yeah it would

@sheslostheplot u need to switch to dawn immediately

@sheslostheplot tfw same bugman app

@pescaincognita lol yea and mfers will go off about girlbosses and capitalism as though its not a basic health thing

@MasterTimBlais @algekalipso We Appreciate Power

@corp_miz @abettertake @eigenrobot yeah i can solve it. among nerds you have to know how, it's sort of like a classical man's education

@corp_miz @abettertake @eigenrobot not quickly like maybe a minute

@abettertake @corp_miz @eigenrobot lol wym

@gbrl_dick damn i love ngos with too much time on their hands i just wish doom was real

@chaosprime @MasterTimBlais @algekalipso send link immediately

@chaosprime @ded_ruckus @MasterTimBlais @algekalipso powerful

tfw the internet is creating standing waves of resonant neuroses

@PrinceVogel @ipsumkyle ngl its mostly a reaction

@pescaincognita grimes mentioned a good point that ive been repeating for a long time & getting called a bugman. pregnancy is unironically basically the last violence inflicted on people on the regular. and yeah, its totally necessary violence, but better world is possible

@pee_zombie its a subset of egregore

americans will literally have the leviathan might of overwhelming military & cultural domination pointed at your face and believe they're the underdogs

it takes a paranoid schizophrenic to believe this but thankfully paranoia is a highly adaptive trait

@MegaBasedChad fax i also talk about tech bros in the third person

@Mimi_Rose_01 @MegaBasedChad brutal

@alth0u guy who’s mind is an infohazard to mfs with good theory of mind

@alth0u when neuralink is invented we'll all taste the mind of the corn syrup account and civilization will end

@yonyui_ just pump the oxytocin

algostables are so cool I just wish control theory was real

@yonyui_ Yes

@bennhoffman @Mimi_Rose_01 @MegaBasedChad Gotta throw u a bone

@deepfates Based or cringe tell me rn

@TheCaptain_Nemo Lmao

@luke_metro Lol if public stocks are taking a beating private ones are taking even more massive Ls due to discount rates

there is no “belt and road initiative”. it’s yet another post hoc rationalization to justify emerging markets infrastructure projects deemed too shitty by american companies

the west took all the good projects long ago except for maybe the high corruption ones but these tend to matter least

@jeff82874662 hey Jeff aren’t you a debt lord? You wouldn’t touch these projects with a 10 foot pole

debt trap peonage was invented by the west and so it loves to impute its own motivations onto foes

@powerbottomdad1 @jeff82874662 Oh debt lord my debt lord

im in my Richard Hanania era

@reallymemorable lol of what use is owning a Ugandan airport

@Whiskeypunk1 My job is to destroy branding with cold shape-ocratic nihilism

@growing_daniel @oscaroverflow Jump in foreign investment does not equal a concerted geopolitical effort It means increased foreign investment

@growing_daniel @oscaroverflow Each level of the chinese state doesn’t even agree on what BRI entails only some vague notion of infrastructure projects running out of steam at home and the need to look for foreign customers

@growing_daniel @oscaroverflow ROI at home is bad and ROI abroad is even worse - double bind

@andrejwagmi sexual selection > natural selection

@Noahpinion this seems silly to me seeing as even the most geopolitically advantageous ports like the Sri Lankan one have not been turned into military ports

@Noahpinion not to mention even if it's true it's not super nefarious considering the breadth and spread of NATO military bases

@jeff82874662 😍

@Noahpinion rich countries will spend more and more on healthcare pushing into the territory of diminishing returns -> sign of abundance, not failure true re: aircraft carriers but again this is a symptom of peacetime profligacy

@fakegeekguy @jeff82874662 sphere of influence in mostly irrelevant underedeveloped countries is not the prize you think it is though. not to mention most infrastructure debt trap defaults still go to the west

@WillManidis great way to get invited to china by insulting their master plan and calling it cope

@AdamNeumannsCoS yep

@LudditeHacker if anything it's the opposite lol. it's construction firms & merchants skimming billions from chinese coffers and the politicians are reduced to spinning nice narratives over it

water beneath the golden gate looking real nice today ... https://x.com/tszzl/status/1392623470119370752

@juicylifeforce wow rude

The ML methods we create for protein structure prediction are the rare machine intelligence synthesis of verbal sequence understanding and spatial intelligence. Evoformer + Residue gas. a step towards semantic grounding

MSAs are a sequence of tokens that contain semantic information and the residue gas learns spatial and physical intelligence

@__femb0t idk i don't see it too much

@__femb0t CLIP is nice though

@juicylifeforce sorry juicy. how can i make it up 2 u

@juicylifeforce we tricked a rock into thinking

@piva_jonas bro what

@varunramg it's not the complexity but rather the bad poetry of the reply that has me speechless

i love this clown world so much https://x.com/elonmusk/status/1483717933700366336

@Chris_Maer @swapp19902 yes

@Hellachans lol

@GigaBeff @growing_daniel well akshually, ML scientist,

@Noahpinion we have money to flush (but maybe not for long)

@growing_daniel Yeah I got mad a little

@J37746526 Lol

😭😭😭😭

@taimurabdaal even this tweet is proof that im in the arena

@Noahpinion but what is the theory of mind here? why would china invest expecting sri lanka to allow it to turn into a chinese military port? seems like the obvious answer is 'no' and china would've known that

@Noahpinion yeah maybe i underestimate the uncertainty

@reddyAlt @Noahpinion yep

@reddyAlt @Noahpinion yep

@pizdeckakpoebat @Tracktor_tyan we're on 7 continents baby

@KHicksEfficient that's part of his charm

@monodevice Lmaoo

having a large twitter account is like being a local car dealer or something. you end up with a random selection of highly useful people in your DMs

@apoorvasriniva jumping lines at the Cleveland clinic

@AdamNeumannsCoS depending on a few things if it’s the type of company where there’s so much fundraiser money that homies never have to do any technical work themselves then yeah

the only two political poles in the future will be the ones who think psychology matters more than the outside world and the ones who think the outside world matters more than psychology

metaverse vs spacex in short

@bryancsk lol

@ionlazer unironically

@__femb0t of course but they're not politically relevant

@__femb0t ok based new dichotomy just dropped

@Noahpinion isn't this fukuyamas whole thesis

@Noahpinion liberalism is the end of history but people will have to rediscover that over and over

@CXGonzalez_ this is def a different axis

@turtlekiosk yeah im just stating it explicitly

@terronk palo alto car dealers has to be insanely high alpha

@terronk until that dang elon musk got his way

the tesla/elon/spacex engineering approach is a bit confusing. at first glance they highly emphasize "first principles thinking" aka rationalism. drill down to primary problem components and create abstraction ladders from scratch

so then it seems the tsla approach isn't really a tradeoff between rationalism and empiricism but just pareto improvement on both. kinda fucked up. philosophycels btfo yet again

but then also most commentators attribute the success of these companies of bringing the tech company ethos of move fast break things (empiricism) over year long planning sessions drawing specs and such

@CausabonT yeah

@CXGonzalez_ @garybasin c programming is a wordcel activity ...

@0xfbifemboy tbh they werent really much smarter than traditional auto to begin with but eventually got to that level

@CXGonzalez_ @garybasin most programming is not math

@Noahpinion yeah or perhaps technology enables new forms of government

probably a great day to be this caleb guy tbh

@Mimi_Birch yeah true

@eigenrobot global problematic male icon ... it'll be in the 100s

@turnip_shepherd these are the same axis

@bentpurgatory ofc both are useful, who is debating that?

tbh this is a massive success in the Homeric sense. caleb and his everlasting glory https://x.com/JordanUhl/status/1484667680145686534?s=20

thucydides trap is so cool i just wish international relations was real

@terronk in sf? hmu

@powerbottomdad1 met this guy who called himself a "product manager" sound p fake

@redoatz mfer has as many "womb tanks" as he wants

@Coscorrodrift @prerationalist @CXGonzalez_ @garybasin https://x.com/tszzl/status/1479647199294365701?s=20

@nickcammarata @MasterTimBlais easy hack for like a million followers tbh

@nickcammarata @MasterTimBlais gonna start doing boring dry machine learning threads and attach pictures of hot girls

@nickcammarata @MasterTimBlais oh fuck its already working

bullish for shape rotators https://x.com/Noahpinion/status/1484727535883599872

@GigaBeff Alphafold 😌

@youngnemo101 wats that

@arctanno Yo I also watched Troy lol

@chaotic_photon The side effects of the second vaccine dose were far worse for me than omicron was at all (albeit much shorter)

if omicron was worse we would all still be rich rn and that’s fucked up

@monodevice But he won’t invite me on

when Hannibal (he/him) marched 100 war elephants (hes/hims) across the Alps, Gaius Varro (he/they) shat his pants

@aeyokay Just gonna have to take my word for it

I can smell technocapital in the air

@shrubbyfoil Absolutely not

@CkLorentzen So true

@ctjlewis Hahahah

@jeff82874662 Like a hierarchy of abstractions I guess

@MegaBasedChad @pujaarajan @Upwork Yeah can do it informally I guess

the United States Postal Service delivers around 170million pieces of First Class mail every single day, averaging to 2000 pieces of mail per second. The ethereum blockchain can handle around 30 transactions per second

@LucreSnooker Lol

ts kind of fucked how my parents traveled across the world with the hopes of sending their kids to some of the worlds best schools but even the worlds best schools are basically shit shows

@halvorz hyperstimulus for humor human mind wasn't made to handle this

@typecfemale wdym

@ahabs_migraines HS. imo the colleges are kind of fucked but show promise

@dcwych sometimes you just gotta appreciate the aesthetics

@varunramg lol im talking about k-12 schools though

i mean K-12 btw

@atroyn wanna try clubhouse?

@powerbottomdad1 clearly you can't see the mental damage

doing a clubhouse bc twitter spaces does not work apparently https://www.clubhouse.com/room/MRDgV1YA https://x.com/atroyn/status/1484966740295520257

i don't think i'm bad as a scientist but i'm better as a propagandist

@jeff82874662 its lowkey a good point tbh this dip is nothing vs the history of bitcoin

@jeff82874662 i mean these guys are just shilling and pumping the bag but still miraculous growth in last ~5 yrs

@jeff82874662 lol facts but my dad was calling me today to gloat abt tesla falling below $1000 and i'm like dad i bought it at $40

this is the future that moldbuggian techno optimist accelerationists want https://x.com/nayibbukele/status/1485031106982428677

@jeff82874662 RIP!

incredible

@wdiamond_econ true, ngmi

@wdiamond_econ to be honest i understand almost nothing about his ideology i just like technology

@halvorz this the keynesian broken window theory

@sdand @michelledavenpt yeah i think growing up with really smart kids is key but also not get ground into dust by the rat race and turned into someone whose not unique anymore

@dcwych @AshtearLucca i think most open ended learning for me fails to impart long lasting knowledge learning things instrumentally as i need them to solve a problem on the other hand tends to stick

@dcwych @AshtearLucca i understood almost nothing about EM waves despite getting an A in 400 level E&M then i had to really learn it to do some chem/optical research and it stuck after that

@__femb0t @halvorz tfw they fact check a joke

@__femb0t @halvorz ik im just teasing

@_metallurgist lol based

@bobpoekert @halvorz despite all the cringe i love dawkins

@MysteryDigital2 ?

@whitewolf_works One time I woke up a kids parents by ringing the bell instead of texting so done with that shit

@ja3k_ Public

@MargibMusic Lmaooo

this is it man. new killer application of AI outside of adtech https://x.com/russelljkaplan/status/1485191276576198656

@halvorz yeah someone needs to do HADDOCK much better

@atroyn the only difficulty with the real world is the cost of collecting data and even that's being bridged https://ai.facebook.com/blog/ai-now-enables-robots-to-adapt-rapidly-to-changing-real-world-conditions/

@atroyn i don't 100% believe this but i am trying to goad you into a response

Chinese fertility is literally worse than Japan’s (a country famous for its low fertility) and y’all are worried about some Bing chillings

@proetrie i think @AlecStapp wrote something on it iirc

@proetrie nvm he just tweeted about it https://x.com/AlecStapp/status/1478495440698068993?s=20

@dayfornuit i never said any such thing

@lisatomic5 tbh both kinds of analysis are useful here agents in large numbers become forces

@keshavadhyay yeah its actually relatively good that we have a high tolerance for extramarital births

@keshavadhyay population falling into terminal decline is decidedly worse than having extramarital babies

@brawnyman713 damn why?

@metakuna not really a fallacy just faulty induction

@metakuna fallacies mostly seem like failures in deductive logic

@brawnyman713 but hasn't it been gone for a while? and yet 10-14 year olds are 115:100

@anon75374998 shannon by far

@Coscorrodrift @vgr @deepfates Wordcel

@civdvs_c @varunramg @man_ruins cheap currency helps build export economy

@stevejohnryan @halvorz Hmm really? It gets to like sub 4 angstrom prediction rmsd - even the resolution of X-ray crystallography is like 3 angstrom

@civdvs_c @varunramg @man_ruins you can delay short term growth for long term prosperity by building an industrial base - at least that’s the chinese thesis

yo it would’ve been so based to be there when Alexander (he/him) rallied the Macedonian army (they/them) at Gaugamela where they saw an eagle (it/its) fly overhead carrying the favor of Zeus (He/Him) and king Darius (he/they) shat his pants fr fr no cap

@growing_daniel Alien of Exceptional Ability

@jeffpicard glad someone noticed

@TenreiroDaniel every few months i have one of these days

this is very bad. tragedy in the making https://x.com/BirthGauge/status/1483013427153022979?s=20

@MowgliPark @growing_daniel he knows why but hes just being performatively bloodthirsty

@alth0u so called free thinkers https://x.com/DogIsABot/status/1485414547150225408?s=20

@shiraeis who is harassing you?

@arapirilous imo its axiomatic that less people is bad. i like people! but moreso than that fewer births means even the people left live more impoverished lives due to the ratio of working age : elder age population shrinking

@ipsumkyle he is far from a rationalist lol

@ionlazer lmao

@lndian_Bronson @IvyAstrix @eriktorenberg a soldier is a person who is dutybound and not a creative; this deontological flow is important for them a founder is the exact opposite. they have no duty to do anything at all and in fact they may be served well by ignoring duties and thinking consequentially

@lndian_Bronson @IvyAstrix @eriktorenberg the greatest companies of the past decades have been started by people who felt allegiance to some technological cause ("connect humanity", "backup mankind on many worlds") and turned their project into a business

@KyleKashuv london: aristocracy SF: power (private sector)

@generativist this is possible because what you do may give you specific alpha in capital allocation

@dcwych @stevejohnryan @halvorz >The overall median is 1.46 Å r.m.s.d c_alpha of test set in AF2 paper so i gave wrong number

@dcwych @stevejohnryan @halvorz i know they're not exactly comparable but my point was the predictions are probably reaching the threshold of accuracy where deviation from the ground truth structure is itself questionable

@BasedBeff tell me more

@BasedBeff correct but the difficult work of collecting this data has been done and compiled into the PDB by 100s of steadfast protein scientists

@BasedBeff I think people are moving goalposts with the protein dynamics stuff - it’s true but not a deal breaker at all. The static low energy structure alone unlocks plenty of alpha

@BasedBeff What’s more it seems that AF2-multimeric is quite good at predicting end state protein complexes without knowing intermediate folding dynamics and exact conformational distribution

@Noahpinion @Mimi_Peacock @edavidds https://x.com/MegaBasedChad/status/1470549518433370113?s=20

life is really about making people like you enough so that you can schizo rant to them and they don't leave

@dcwych @stevejohnryan @halvorz you're 100% right but also too pessimistic imo reading about the history of rational drug design we've made some wild jumps in experiments to try with far lower caliber input than "high confidence extremely accurate structure prediction"

@dcwych @stevejohnryan @halvorz these methods don't need to be some golden bullet that accurately predict all structures & interactions in all cases to have utility - if you can even bias some HTS and have increased hit rates it's probably already useful

@dcwych @stevejohnryan @halvorz at the very least we can say that big pharma considers it worthwhile to pour some gas on these experiments vis a vis all the partnerships with AI biotech plays

@bobpoekert @zetalyrae you'd be shocked how much fish farms rely on externalizing many costs to healthy oceans

@bobpoekert @zetalyrae where do you think we build them?

@Noahpinion i see you've read permutation city

@eurydicelives femininity is capital and masculinity is labor,,

@eurydicelives but most men will spend their life wanting to leave the working class and enter the capitalist class 👀

@eurydicelives up until maybe 250 years ago they were one and the same

@eurydicelives lol ive been on here for a while and ive seen some schizo Takes. one of my favorite was some marxist saying we should tax beautiful women

@eurydicelives yes to support my terrible theories

@eurydicelives 🤧😎

@eurydicelives just to be clear im trolling a bit bc now is the hour of unhinged convos but the metaphor is apt

@Mimi_Peacock @eurydicelives @Rididelduol we should tax people based on their # of twitter followers

if you don't believe in the natural gravity of capital then just run a twitter account and watch the exponential growth in followers for doing the same amount of work

@joodaloop @eurydicelives @Rididelduol @Mimi_Peacock so true

@joodaloop @eurydicelives @Rididelduol @Mimi_Peacock capital is when you have a girl pfp (or even vibes) and get 1000 followers without doing anything. labor is when you're an anon tweeting 20 bangers a day in the mines

@ks_kulk wait elaborate this feels like a great metaphor

@ks_kulk ah right so its just momentum, i thought there was a specific angle on the nesterov thing lol

@chrisgardenuk @Mimi_Peacock @eurydicelives @Rididelduol unrealized cap gains when you get profile views but they dont follow

@mehran__jalali based

@Mimi_Peacock @chrisgardenuk @eurydicelives @Rididelduol what in gods name is going on here, why is my conversion rate so low

fukuyama's "End of History" doesn't necessitate that any individual state lives forever but rather that no better systems than liberalism are ultimately possible. in his logic the american empire can collapse and history can still be over

fucccc i took melatonins now im just schizo poasting at half IQ instead of sleeping

@dcwych @stevejohnryan @halvorz it looks like the 1st ex. of this was in the 80s when a group noticed that ACE probably looks sort of like BPA (which they had a crystal for) and this lead to the creation of ACE inhibitors i mean if you can get signal from models that vague then your bar seems way too high

@dcwych @stevejohnryan @halvorz maybe im thinking about this wrong and all the low hanging fruit has been tapped in 40 years but the methods are getting better too

@dcwych @stevejohnryan @halvorz Yeah I buy that

@halvorz @dcwych @stevejohnryan some other similar zinc protein apparently

@dcwych @stevejohnryan @halvorz structural bio people are far from obsolete just a handful of boring work for them has just been automated these tools should make you guys more powerful

@halvorz @dcwych @stevejohnryan Yeah my b that’s the one

when I learn that markets don’t always go up

@0x49fa98 wordcels pay no mind

ADL will put wordcel on their list of slurs before this year is out

@neurotopology yeah i am going to

@gaberivera @NYT_first_said Oh man

@MMMalign Good call

guy who GMOs a plant that synthesizes a protein under drug patent, lets it proliferate in the wild, argues in court that the protein is naturally occurring and therefore unpatentable, Pfizer stock goes to 0,

@growing_daniel this happened to my buddy Steve

@eigenrobot the convolutional nets are training

@sgodofsk steven i bet you were one of those people

@sgodofsk haha jk ... unless?

@OswaldHurlem the loan just has to be fully collateralized with some other asset

@johngearysquash lol yea you can still have a use patent but i think it invalidates some other kind of patent. either way dont think too hard about it

now that I’m poor it’s time to start selling jpegs

@luke_metro This actually a good idea but the gas fees will impoverish me

moving onto web4

@GarrettPetersen dr. dad no! you will burn her mouth

@AdamNeumannsCoS hahaha

if you can’t pee your pants on command you’re oversocialized

@TheCaptain_Nemo this is ted k's weird screed on leftism

'fb shouldnt have my info so ill make it public to the whole world instead' doesnt seem to be the killer app that many think it is

@peachblvd the people need to know grace

@peachblvd @cauchyfriend let's just say i'm preparing you for the post apocalypse when the social order breaks down and men and women will have to pee on a dime in random places ...

@peachblvd @cauchyfriend lol the latter

@himbodhisattva @peachblvd @cauchyfriend guys not a literal dime

@cauchyfriend @peachblvd @himbodhisattva to be honest i thought grace was asking if 'pee on a dime' was a specific commonly used phrase and i was like uh

@peachblvd hmm doesnt it strip everything of moral value if all the bad things and all the good things are simultaneously happening everywhere

@peachblvd outed as a he/him fuckkk

@peachblvd checkm8

@alth0u its actually definitely 2x but its also fine i can afford it

@growing_daniel @alth0u nope

@himbodhisattva @peachblvd yeah fair honestly i was just spitballing

@himbodhisattva @peachblvd the zooming out is fine for me bc i spend enough time reading scifi to be inoculated from most brainfucking it's more that infinities start breaking both my logic and my intuition

@alth0u yep

this thread is great fun but honestly makes zero sense. but the best part is accusing yc/stripe of manipulating hacker news results as though anyone reads that trash https://x.com/ryanbreslow/status/1485784823641755648

@dcwych @stevejohnryan @halvorz look it's already happening https://arxiv.org/abs/2201.09647

@negroprogrammer lmfaoo

@RahmSJ what means?

hahaha https://x.com/negroprogrammer/status/1485896929175212037?s=20

@bloooooomberg @gbrl_dick lmfao

@bloooooomberg @gbrl_dick followed

@gbrl_dick incredibly good day for ireland memes

bullish af https://arxiv.org/pdf/2201.09647.pdf

@dcwych @stevejohnryan @halvorz >7 synthesized compounds and they generate a high affinity lead this is far from my pessimistic case of just biasing some high throughput screens it's actually just straight up in silico lead identification

@dcwych @stevejohnryan @halvorz the paper is very industrial and reads like an advertisement but still i think both of you are being too bearish on in silico affinity prediction

@ollyrobot i should also be able to get a DNS for physical addresses from my govt, no more of this changing 1 million website's delivery options every so often bullshit

@ollyrobot it doesnt need universal adoption to be useful govt creates a dns book for addresses and eg amazon can opt into taking address domains and then user can opt into giving address domains

@ollyrobot iirc japan already does this

@ollyrobot but yea i agree the email dns thing seems like a more basic requirement along with a very basic bank account

@ollyrobot (speaking from usa perspective) tbh bank accts should be logical entities spun up by the Fed with derived classes created by consumer banks that offer features on top the current method offers only an illusion of independence from govt alongside painful KYC and late settlement

@eigenrobot mission San Francisco? I’m around if you’re around boss

@dcwych @stevejohnryan @halvorz yeah I’m well aware of dynamics problems, just got done listening to a guys lecture on cryptic pockets

@dcwych @stevejohnryan @halvorz But also as this paper is an existence proof that maybe there’s a set of drug binding problems where (1) theres a good target identified (2) real crystal structure is unavailable (3) dynamics are not too relevant for the given affinity problem then we’re cooking with gas

@dcwych @stevejohnryan @halvorz the size of this set seems to be the interesting variable … so I’m curious, what % of crystallized structures have proven to be undruggable?

@dcwych @halvorz @stevejohnryan It’s an arxiv preprint it’s staking credit so they can publish a bigger paper later - but now InSilico can say “hey we got the first alphafold related drug lead”

@halvorz @stevejohnryan @dcwych Lol non ML people may be a little confused by why they do things like this but: https://x.com/tszzl/status/1486037887665639425?s=20

@dcwych @stevejohnryan @halvorz and these structure problems are pervasive across all protein types or limited to an understood subset of folds?

@dcwych @halvorz @akbirthko @stevejohnryan I don’t think there’s any adversarial relationship between bio and ML at all I’m just trying to figure out whether my company is going to go belly up

@KHicksEfficient I actually like the digital ownership part + related financial infrastructure

@BroductManager im living in your mind rent free

@dcwych @halvorz @stevejohnryan reading this again i think insilico is just doing PR and they don't have a great reputation either

@dcwych @halvorz @stevejohnryan i love stanford startups .... roughly 70/30 chance of total crackpot or completely game changing

@dcwych @halvorz @stevejohnryan i remain hopeful that they put out more info on this tho overall what amazes me about AF & AF-multimeric was the amount of information that was hiding in the evolutionary history beating out all physics based approaches -- makes me think theres a lot more to do here

@dcwych @halvorz @stevejohnryan even in binding problems that involve complex dynamics i can no longer conscionably think the best way to approach the truth is running insane MD simulations

@dcwych @halvorz @stevejohnryan lol this'll be a tough sell but AF2 is a relatively small model with a humble inference compute demand - you could run the final version on commodity hardware at home on proteins below a certain size

@dcwych @halvorz @stevejohnryan yeah but 'you get what you train for' is kind of hiding some insane poorly understood generalization capabilities

@dcwych @halvorz @stevejohnryan this sounds fun im in

my next company needs to be only insane schizo online degenerates. we will have a private mastodon instance instead of slack. no professionals no suits no phd grads only r*tards

@SockJustSock thats acceptable yes

actually phds are allowed as long as they have a history of poasting through it

@lorenpmc @_metallurgist @eigenrobot down

@eigenrobot @lorenpmc @_metallurgist sounds good man no pressure

@OdiliTime an invite to what exactly

can devs do something? https://x.com/atroyn/status/1486076624952983552

apparently @quantumVerd has turned me into a quantum ghost! i don't quite get it but i am told this is produced on a quantum computer simulating the early universe biased towards a certain image

@quantumVerd https://x.com/quantumVerd/status/1428679478243434499

@houellebecq_2 ye

@__femb0t and they say Big Science doesn't have an agenda

@__femb0t that's the agenda

@__femb0t im joking miss fembot

@krrishd brooooo

@saltylimesoda mostly just slide decks

@deepfates boring truth for me; exciting fiction for thee

@chaosprime @deepfates hmmm

@bastard_brian anyone who has escaped the siren song of fentanyl is basically the mental elite

@nikitabier most of the cool cypherpunk stuff was built on smokefilled IRC rooms now?

@gbrl_dick all modern food scarcity is caused by political failure so this is really a UN vote for toppling West African despots and such

@gbrl_dick also I think its not a half bad human right (much better than the very nebulous “housing” because it has an objective measure: is the individual starving)

@conorduffy_7 @halvorz someone explain to me rn which is the Autist which is the schizo

@conorduffy_7 @halvorz what’s nice about Watson & crick is that their insight is pure shape rotation

“longtermism is dangerous” L + ratio + yuor an enemy of humanity https://x.com/timnitGebru/status/1485405723802562562

@michaelcurzi @myceliummage @BroductManager Hmu

@telmudic What happened?

watch this space https://x.com/zebulgar/status/1486368347306409987

the first derivative here should be interesting … if 2022 has more people than 2021 they rly memed Miami tech into existence and the internet reins supreme

@WillManidis Yeah but I’m built different

@eigenrobot were all laughing at u

@BroductManager Big if true

the “Stripe East India Company” has colonized my people and is forcing them to work long hours in the payment fraud mines. Irish goons have kneecapped all resistance leaders. pls send help

@anadoie only joke for 2022

@nigelomics no but @zebulgar and i have forged a friendship in the starcraft ladders

if a white guy knows what an igbo is that's a red flag

@Noahpinion can you get us a meeting with hideaki anno

@AnyaMartin8 nice one

@AnyaMartin8 the joke is the folks that tend to know most about niche ethnic minorities are the racists lmao

@Noahpinion absolutely, i would go fanboy mode. idk if he speaks english though

@eigenrobot lol i stayed at the same place as you and the maids would constantly tell me its the cleanest room theyve seen all day

the biggest blackpill is that i was trying to rotate out of stocks 2-3 weeks ago but got caught up in an autistic exploration of ZEBRAs

@arctanno You know exactly why

Guys it’s a real phrase smhhhh

@Ephi_BL DM it to me alone and I’ll be that guy

@NLRG_ @DistractedAnna we do occasionally take scenic strolls together and buy pastries

@NLRG_ @DistractedAnna in the Castro

holy shit lmao https://x.com/WeAreMel/status/1485672752510033925

i think this guy is just ingroup https://melmagazine.com/en-us/story/men-rotating-3d-objects-addiction

@alt1na1 I wish … instead it’s the options trading strategy

Ok anyway this garbage revisionist history needs to be brought down. I will be writing my own

@vgr yeah now i see the wisdom in your premium mediocre post

@vgr the follows of a young rotator, https://x.com/tszzl/status/1479647199294365701?s=20

@Noahpinion is*st*ph called out

@Willyintheworld based